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Certain syndromes are associated with an increased risk for cancer. Dutch investigators compared physical examination findings of 898 consecutive patients from a childhood cancer follow-up clinic (median age, 21 years) and 175 children newly diagnosed with cancer (median age, 6 years) with findings of 1007 healthy children (median age, 11 years). Because ethnicity might influence external phenotype, only white children were included in the study.
The most common types of cancer were acute lymphoblastic leukemia (18.2%), nephroblastoma (12.8%), and non-Hodgkin lymphoma (11.7%). Major and minor morphologic abnormalities were significantly more common in cancer patients. Abnormalities included blepharophimosis, prominent ears, and asymmetric lo…