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Cough in children with upper respiratory infections (URIs) is a frustrating symptom for children and their caregivers. Evidence is weak for the efficacy of pharmacologic interventions against cough, such as dextromethorphan (DM), diphenhydramine, and codeine; all have been associated with adverse effects in children (Journal Watch Pediatrics and Adolescent Medicine Sep 12 2007 and Feb 14 2007). To examine whether honey is a safe and effective alternative, investigators randomized 105 children (age range, 2–18 years) with URIs and disruptive coughs for 7 or fewer days to receive one dose of honey-flavored DM (8.5 mg–34 mg/dose, based on age), an equivalent volume of buckwheat honey, or no treatment 30 minutes before bedtime. Parents complete…