Malaria — A Potential Vaccine and New Treatments

The treatment of children with malaria must be based on knowledge of the specific organism and local resistance patterns.

Malaria kills an estimated 800,000 children annually worldwide and infects hundreds of millions of other children. Three studies provide information on the efficacy and safety of malaria vaccines and treatments in infants and children.

In one industry-sponsored, double-blind, randomized trial, 894 infants (age range, 5–17 months) in Kenya and Tanzania received three doses (1 per month) of either RTS,S/AS01E malaria vaccine or rabies vaccine. At a mean follow-up of 8 months, the cumulative incidence of the first or only episode of Plasmodium falciparum infection was significantly lower in the malaria-vaccine group than in the rabies-vaccine group (8% vs. 16%). The rate of serious side effects was lower in the malaria-vaccine group (11% vs. 18…

Reviewing Author

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Malaria — A Potential Vaccine and New Treatments

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Reviewing Author