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Results of previous meta-analyses have suggested that thickening infant formula (e.g., with rice cereal or carob bean gum) does not reduce gastroesophageal reflux (GER), but findings of more-recent studies not included in those meta-analyses are more encouraging. To further evaluate the efficacy of thickened formula, investigators conducted a meta-analysis of data from 14 randomized, controlled trials that involved 877 infants (age, <24 months) with GER.
The findings were remarkably consistent. Compared with standard formula, thickened formula significantly reduced episodes of regurgitation and vomiting in infants as reported by parents and physicians. Use of thickened formula was associated with a significant increase in weight gain (about …