Early Predictors of Response to Atomoxetine

A 25% reduction in core ADHD symptoms by 4 weeks of treatment predicted a good response at 6 to 8 weeks.

The titration phase for stimulant medications (methylphenidate and amphetamine) for children and youth with ADHD typically takes 2 to 4 weeks. In contrast, the effect of the nonstimulant atomoxetine on core ADHD symptoms can take 6 to 8 weeks. In an industry-funded study, investigators pooled data from six randomized controlled studies to identify predictors of response to atomoxetine before 6 to 8 weeks. Of 1069 patients (age range, 6-18 years), 618 were randomized to atomoxetine.

By the end of the 6-to-9-week studies, 40% of patients were nonresponders, 47% were considered much improved (based on a ≥40% reduction in total score on the ADHD Rating Scale), and 13% had minimal responses. Although no baseline variables predicted much improved …

Reviewing Author

Martin T. Stein, MD

Disclosures

Consultant / Advisory boardPearson Neuroscience Advisory Board

Speaker’s bureauAmerican Academy of Pediatrics

RoyaltiesElsevier, Inc.

Editorial boardsJournal of Developmental and Behavioral Pediatrics