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Although sporadic cases of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection have been reported, oseltamivir remains an important tool in our armamentarium against flu. In July 2009, two girls residing in the same camp cabin in North Carolina developed oseltamivir-resistant 2009 (H1N1) virus infection while receiving oseltamivir as part of a mass prophylaxis program during an influenza outbreak. Both girls recovered fully. Whether the one girl case transmitted the virus to the other or whether both girls were infected by another camper is uncertain. One girl continued to receive prophylactic (not therapeutic) doses of oseltamivir during the first 4 days of her illness, which could have contributed to the development of …