Screening for Pediatric Inflammatory Bowel Disease

The IBD Serology 7 panel offers little value over routine blood tests.

A screening test for inflammatory bowel disease (IBD) should be inexpensive, minimally invasive, and accurate. In a retrospective chart review of 304 children (age, <21 years) who had undergone IBD testing at a single pediatric gastrointestinal clinic in Massachusetts, researchers compared predictive values of the IBD Serology 7 panel (IBD7) — which includes specific markers for IBD (including anti-CBir1) and a pattern recognition algorithm — with routine laboratory tests (hemoglobin level, erythrocyte sedimentation rate, and platelet count).

Final diagnoses were based on endoscopic, histologic, and radiographic criteria. Thirty-eight percent of children received diagnoses of IBD. The sensitivity, specificity, positive predictive value, and …

Reviewing Author

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)