IV Volume Expansion Reduces Risk for Oliguria in Hemolytic Uremic Syndrome

Volume expansion during the first 4 days of diarrhea was renoprotective.

No therapy has been shown to prevent hemolytic uremic syndrome (HUS) after enterohemorrhagic Escherichia coli O157:H7 infection. In a prospective observational study, investigators examined the clinical courses of 50 children (age, <18 years; mean age, 4 years) at 11 children's hospitals in the U.S. and Scotland who met criteria for diarrhea-associated HUS (hemolytic anemia, thrombocytopenia, and renal insufficiency).

Demographic characteristics, symptoms, and medications were similar between the 34 children who developed oliguria (urine output <0.5 mL/kg/hour) and the 16 who did not. Among children with oliguria, the condition developed within the first 10 day of illness in all but one patient. Children who developed oliguria received signi…

Reviewing Author

F. Bruder Stapleton, MD

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Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

IV Volume Expansion Reduces Risk for Oliguria in Hemolytic Uremic Syndrome

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Reviewing Author