Specific Genes Mediate Stimulant Response Variability in Children with ADHD

Two genetic polymorphisms were associated with individual variability in methylphenidate dose-response among school-age children with ADHD.

Most children with attention-deficit/hyperactivity disorder (ADHD) respond to stimulant medications with a reduction in hyperactivity, impulsivity, and inattention, but individual variability exists regarding optimal dosage and duration of effect. Researchers examined the role of four candidate genes previously associated with ADHD in mediating the effect of methylphenidate (MPH) response in 89 stimulant-naive children (age range, 7–11 years) with ADHD.

As part of a 4-week randomized, double-blind, crossover trial, each child received 1 week of placebo or three different dosing schedules of a long-acting osmotic-release oral system of MPH (dose range, 18–54 mg). Parents and teachers assessed each child's response using the Vanderbilt ADHD ra…

Reviewing Author

Martin T. Stein, MD

Disclosures

Consultant / Advisory boardPearson Neuroscience Advisory Board

Speaker’s bureauAmerican Academy of Pediatrics

RoyaltiesElsevier, Inc.

Editorial boardsJournal of Developmental and Behavioral Pediatrics

Martin T. Stein, MD

Disclosures

Consultant / Advisory boardPearson Neuroscience Advisory Board

Speaker’s bureauAmerican Academy of Pediatrics

RoyaltiesElsevier, Inc.

Editorial boardsJournal of Developmental and Behavioral Pediatrics