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In 2010, California suffered a large pertussis outbreak; in addition to significant infant mortality, a high disease burden was seen in 7- to 10-year-olds. Investigators used 2010 data from 15 California counties to examine the association between pertussis and time since completion of the five-dose diphtheria, tetanus, and acellular pertussis (DTaP) series.
Among 682 pertussis cases in children aged 4 to 10 years and 2016 controls, cases were significantly more likely than controls to be unvaccinated (7.8% vs. 0.9%) and to be older (median age, 9 vs. 7 years). Unvaccinated children were 8.9 times more likely to contract pertussis than fully vaccinated children. Among children who completed the five-dose series, the odds for pertussis increa…