Children with a Solitary Kidney Require Long-Term Clinical Follow-Up

Many children show signs of renal injury during childhood.

A reduction in nephron number leads to “hyper” glomerular filtration and increases risk for renal injury. Children born with a solitary functioning kidney (SFK) present the opportunity to examine the risk for renal injury and when signs are likely to develop.

Investigators retrospectively evaluated medical records of 407 children with SFK (congenital SFK, 203 patients; acquired SFK, 184 patients) from two medical centers in the Netherlands (mean follow-up, 9 years). Children with acquired SFK were older than children with congenital SFK and were more likely to have congenital anomalies in the SFK and relapsing urinary tract infections. By a mean age of 6 years, 37% of patients had evidence of renal injury (hypertension, proteinuria, increase…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)