Treatment Guidelines for Steroid-Sensitive Idiopathic Nephrotic Syndrome in Children

Steroid-sensitive nephrotic syndrome during childhood is frequently a chronic condition.

Sponsoring Organization: Kidney Disease: Improving Global Outcomes (KDIGO)

Target Population: Clinicians worldwide

Idiopathic nephrotic syndrome is a relatively common glomerular disease in young children. Although 80% of patients respond to treatment with corticosteroids, numerous treatment regimens are practiced worldwide. As many as 90% of children with steroid-sensitive nephrotic syndrome experience relapse, but proper initial therapy can reduce relapse risk. These guidelines address management of steroid-sensitive nephrotic syndrome in children aged 1–18 years.

Key Points:

Definition of nephrotic syndrome: edema, urine protein:creatinine ratio ≥2000 mg/g; urine protein ≥300 mg/dL, dipstick urine protein 3+, hypoalbuminemia ≤2.5 mg/L

Initial…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)