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Studies of cognitive benefit from aspirin and other anti-inflammatory agents have yielded mixed results. The Women’s Health Study was a large, randomized, placebo-controlled study of vitamin E (600 IU on alternate days) and low-dose aspirin (100 mg on alternate days) for the prevention of cardiovascular disease and cancer. In this 4-year subgroup analysis of approximately 6400 women 65 or older, investigators administered tests of general cognition and verbal memory by telephone interview at 2-year intervals to women who had already received aspirin or placebo for an average of 5.6 years.
Global scores for cognitive function and scores for verbal memory did not differ between the two groups at initial testing, and the mean decline in overall…