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Pregnancy rates generally decrease as women age, a likely reflection of the increasing numbers of chromosomally abnormal embryos. In women of advanced maternal age who are undergoing in vitro fertilization, pregnancy rates theoretically should increase if embryos are prescreened and only chromosomally normal embryos are transferred. In this study, 408 women (age range, 35–41) scheduled to undergo IVF in one of two Dutch centers were randomly assigned to standard IVF with or without (control) preimplantation genetic screening (PGS) and were followed for three cycles. No more than two embryos were transferred during any one cycle.
In both the PGS group and the control group, approximately one third of the participants discontinued treatment (7…