Elevated Cervical Cancer Risk Continues for Decades After CIN 3 Treatment

For 25 to 30 years after treatment of CIN 3, women are at increased risk for cervical and vaginal cancer.

Quantifying the risk for invasive cervical cancer after treatment of precancerous lesions is important in optimizing follow-up. Investigators used Swedish cancer registry data from 1958 through 2002 to determine whether 132,000 women who were treated for cervical intraepithelial neoplasia grade 3 (CIN 3) had a greater risk for invasive cervical or vaginal cancer than did women in the general population.

Overall, women with previous CIN 3 were more than twice as likely to develop invasive cervical cancer than were women in the general population (standardized incidence ratio, 2.3). Risk for cervical cancer increased further with age at treatment, accelerating most after age 50. There has been a trend for increasing risk with each decade since…

Reviewing Author

Wendy S. Biggs, MD

Elevated Cervical Cancer Risk Continues for Decades After CIN 3 Treatment

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Reviewing Author