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Hormone therapy’s effect on dementia incidence has remained unresolved for menopausal women and their clinicians. In a study of 3000 women in a California HMO (mean age at study entry, 79), investigators compared cognitive status in women who had used HT continuously from 1992 to 1998 with cognitive status in those who had not. Women completed telephone questionnaires at baseline in 1999 and annually through 2003; medical records were used to confirm incident dementia. Participants also reported their ages at menopause and at HT initiation.
More than half of the participants used HT. The mean self-reported duration of HT use was 31 years for estrogen therapy (mean age at initiation, 48) and 23 years for combination estrogen-progestin HT (mea…