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Antiepileptic drugs (AEDs) have adverse effects on bone health, but longitudinal studies of single agents have been lacking. Investigators evaluated bone loss during 1 year in 93 premenopausal women with epilepsy (age range, 18–40) who were receiving AED monotherapy with carbamazepine (41 women), lamotrigine (23), phenytoin (15), or valproate (14). Measurements at baseline and 1 year included lumbar spine, femoral neck, and total hip BMD, as well as biochemical markers of bone metabolism. All women completed nutritional and activity questionnaires; data on duration and dose of current AED treatment and total duration of AED treatment also were obtained.
Participants reported that they were physically active, generally with daily calcium inta…