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Experts generally recommend a minimum of 30 minutes of moderate-intensity activity on most days of the week (150 minutes weekly), but substantially more exercise probably is necessary to lose weight and to keep it off. Investigators randomized 191 overweight and obese women who were attending a weight-loss clinic into four groups: high or moderate energy expenditure (2000 vs. 1000 kcal/week) in the form of vigorous- or moderate-intensity exercise. Participants also were instructed to maintain a prescribed, reduced-caloric intake; all received intensive weight-loss counseling, regular group visits, and periodic telephone contact. Previous data from this study showed that average 12-month weight losses of 10% and 8% from baseline were associa…