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Breast cancer is relatively uncommon among women of reproductive age. However, as age at pregnancy continues to rise in the U.S., clinicians will encounter more women with pregnancy-associated breast cancer (PABC, breast cancer diagnosed during or within 1 year after pregnancy). In a retrospective cohort study performed at a large U.S. cancer center, investigators reviewed records of women with breast cancer diagnosed at or before age 35 who were treated from 1973 to 2006. Women with inflammatory breast cancer, ductal carcinoma in situ, or breast sarcoma were excluded.
Of 668 breast cancers in 652 women (median follow-up, 91 months), 104 were classified as PABC (51 diagnosed during pregnancy; 53 diagnosed within 1 year after pregnancy). Over…