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Some 40% of women who have early (i.e., stage IB–IIA) invasive cervical cancer are candidates for radical hysterectomy, a surgical procedure that was developed more than a century ago. Total mesometrial resection (TMMR) is a surgical technique that was developed based on observations that early-stage cervical cancer remains confined to the embryologically defined Müllerian compartment (fallopian tubes, uterus, upper and middle vagina, and surrounding peritoneal and subperitoneal tissue [mesometrium]); accordingly, risk for locoregional cancer recurrence and morbidity could be lower than that associated with standard radical hysterectomy. Now, investigators in Germany have conducted a prospective analysis that involved 212 women with stage I…