Cervical Cancer Risk Among Women Who Have Been Treated for CIN

For women who have been treated for cervical intraepithelial neoplasia (CIN), consensus about optimal surveillance strategies has not been reached. In a population-based cohort study, Canadian researchers compared cytologic and cancer-registry data from more than 37,000 women who had been treated for CIN 1, 2, or 3 with data from nearly twice as many women who had no CIN histories.

Overall cumulative rates of CIN 2 or CIN 3 during the first 6 years after treatment were 14.0% for women who were originally treated for CIN 3 and 9.3% and 5.6% for those who had been treated for CIN 2 and CIN 1, respectively. Thirty-seven invasive cancers developed in the CIN cohort and six cancers occurred in the comparison cohort. After 6 years, annual rates of…