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Radiation therapy to the chest early in life raises risk for breast cancer, and irradiation that involves the pelvis attenuates ovarian function. Investigators performed a case-control analysis involving participants in the Childhood Cancer Survivor retrospective cohort study who received radiation therapy from 1970 through 1986. Radiation dosimetry and location were assessed among 120 women who subsequently developed breast cancer and 464 women who did not.
The initial cancer was Hodgkin lymphoma (HL) in 65% of cases and 40% of controls. Median time from first cancer to breast cancer was 19 years; 80% of cases had invasive primary breast cancer. Receipt of any radiotherapy was associated with higher risk for subsequent breast cancer (odds r…