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Every year, one in three older adults (age, ≥65) experiences at least one fall, which makes fall prevention an important public health issue. Researchers performed a meta-analysis of eight double-blind randomized controlled trials to evaluate the effect of oral vitamin D supplementation on risk for falls in 2624 older adults (81% women).
High-dose vitamin D (700–1000 IU daily) was associated with 19% lower fall risk (number needed to treat, 11 people for 2–36 months). Low-dose vitamin D (200–600 IU daily) did not attenuate risk significantly. Serum 25-hydroxyvitamin D3 (25[OH]D) levels of ≥60 nmol/L lowered fall risk by 23%, whereas concentrations <60 nmol/L had no significant effect. Subgroup analysis suggested that the effect of vitamin D …