In Ugandan trials, adult male circumcision was associated with a 28% reduction in prevalence of high-risk HPV in female partners.
Male circumcision lowers risk for transmission of HIV, herpes simplex virus type 2 (HSV-2), and human papillomavirus (HPV) in men (and acquisition of bacterial vaginosis and trichomoniasis by their female sex partners). In a study of participants in two circumcision trials in Uganda, investigators asked whether male circumcision lowers risk for HPV acquisition in participants' regular female partners. Circumcision was performed at trial entry (intervention group) or at 24 months (control group). At enrollment, 12 months, and 24 months, women self-collected vaginal swabs for HPV testing and genotyping.
At enrollment, 35% of 648 women with partners in the intervention group and 37% of 595 women with partners in the control group tested positiv…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)