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The prevalence of mood disorders in reproductive-age women makes the safety of selective serotonin reuptake inhibitor (SSRI) use during early pregnancy an important issue. Finnish investigators performed a retrospective national cohort study of maternal SSRI use and incidence of major congenital anomalies (including pregnancy terminations performed because of severe malformations) to evaluate outcomes in 6976 offspring with first-trimester SSRI exposure in comparison with 628,607 unexposed offspring. Women who used SSRIs during early pregnancy were less likely to be married, twice as likely to smoke or to have chronic diseases, and 20 times more likely to have purchased non-SSRI psychiatric medications than were women who did not use SSRIs.…