Cervical cancer risk was 75 times higher in women with persistent carcinogenic HPV infections than in those who were HPV-negative.
The standard approach to lowering cervical cancer risk involves assessment and follow-up of cytologic abnormalities; however, progress in our understanding of the role of human papillomavirus (HPV) in carcinogenesis has shifted the focus to HPV infection. In a longitudinal study, investigators assessed persistent infection with carcinogenic HPV types as a predictor of cervical cancer in a cohort of Taiwanese women (age range, 30–65). Persistent infection was defined as two positive tests 2 years apart. At baseline, 12,000 women were tested for 39 HPV types; 6923 women were retested 2 to 5 years later.
During a mean follow-up of 14.5 years, 68 women received diagnoses of cervical cancer. Overall risk for cervical cancer was 75 times higher in…
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)