Does Ovarian Stimulation for In Vitro Fertilization Raise Risk for Ovarian Cancer?

Women who underwent IVF had excess risk for ovarian malignancies, particularly borderline tumors.

Multiple ovulations and follicular punctures associated with in vitro fertilization (IVF) might raise risk for subsequent ovarian malignancies, but data have been contradictory. Investigators conducted a cohort study of 19,146 women who received IVF treatment in the Netherlands and a comparison group of 6006 subfertile women who did not undergo IVF. Incidence of ovarian malignancies and borderline tumors (low-grade, unaggressive malignancies) was determined from nationwide disease registries.

At median follow-up of 14.7 years, 42 invasive ovarian malignancies and 35 borderline tumors had occurred overall. Compared with the general population, the IVF group — but not the non-IVF group — had significantly higher risk for borderline tumors (sta…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Does Ovarian Stimulation for In Vitro Fertilization Raise Risk for Ovarian Cancer?

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Reviewing Author