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Vasomotor symptoms are experienced by more than three quarters of women during the menopausal transition. The Daily Hormone Study (a subset of the Study of Women's Health Across the Nation) was conducted to evaluate presence of vasomotor symptoms (VMS) and their relation to mood. A total of 625 women (age range at entry, 42–52) completed this 3-year study. Participants maintained daily diaries of mood and physical symptoms during the previous 24-hour period for one menstrual cycle or 50 days, whichever was shorter.
In all, 52% of participants reported ever experiencing VMS during the study period; of these, only 6% reported daily VMS. Occurrence of VMS was significantly associated with negative mood within each 24-hour period, but the relati…