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In 2008, the U.S. Preventive Services Task Force (USPSTF) reaffirmed its prior stance that the harms associated with screening for ovarian cancer exceeded the benefits. Now, the task force has confirmed this guidance based on updated evidence from U.S. and U.K. randomized controlled trials.
In the 2011 U.S. study (JW Womens Health Jun 16 2011), women were randomized to usual care or screening with vaginal ultrasound and CA-125 testing; 17% of participants had family histories of breast or ovarian cancer. Although marginally more cases of ovarian cancer were identified among screened women, stage at diagnosis and mortality did not differ between screened and unscreened women. The ratio of oophorectomies to screen-detected ovarian cancer was 2…