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Younger breast cancer survivors' quality of life can be adversely affected by treatment-induced menopausal symptoms. Hormone therapy is often contraindicated, and nonhormonal pharmacologic treatment is available but less effective. Nonpharmacologic interventions offer an alternative approach. Dutch investigators randomized 422 disease-free breast cancer survivors (aged <50; premenopausal at cancer diagnosis) who were experiencing menopausal symptoms to one of four groups: cognitive-behavioral therapy (CBT; 6 weekly 90-minute group sessions followed by one refresher 6 weeks later), physical exercise (PE; 12 weeks of individually tailored 2.5–3.0-hour weekly home sessions), CBT plus PE, or no structured intervention. General menopause-related…