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Reproductive and sexual dysfunction is common in women who survive cancer during childhood, adolescence, or young adulthood. Adverse sequelae vary depending on cancer type, age at diagnosis, and treatment. Because complications can arise during or long after treatment, clinicians should counsel patients and their parents in a developmentally appropriate way before initiating therapy, and then evaluate patients periodically for abnormalities.
The Children's Oncology Group has reviewed the current recommendations for management of asymptomatic cancer survivors who present for follow-up >2 years after completing therapy. Highlights of the guidelines are as follows:
Hypogonadism can result from radiation to the ovaries or hypothalamic-pituitary (…