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Although most epidemiologic studies have not shown an association between cosmetic breast augmentation and excess risk for breast cancer, concerns persist that implants (which are radio-opaque) may impair mammographic detection of early-stage malignancies. In a review and meta-analysis, investigators evaluated breast cancer stage distribution and survival among women with and without cosmetic breast implants.
Breast augmentation was associated with marginally higher likelihood of having a nonlocalized breast cancer at diagnosis (odds ratio, 1.26; 95% confidence interval, 0.99–1.60; P=0.058). The statistical significance of the association was strengthened when the analysis was limited to studies that only included cases of invasive breast ca…