How Beneficial Is 3D Mammography with Tomosynthesis?

Three-dimensional (3D) mammography with tomosynthesis uses a moving x-ray source to construct a series of thin-section images of the breast. Although this imaging mode has been recommended for high-risk women and those with radiologically dense breast tissue, few studies have addressed its use in routine screening. In a manufacturer-funded prospective study in Italy, women aged ≥48 were invited to receive both 2D and 3D mammography (performed during a single compression of the breast) as part of their routine screening. Each radiologist interpreted images sequentially, first using standard 2D mammography, then (on the same day) using an integrated 2D/3D image. Radiologists determined whether to recall women for additional evaluation after r…