Oximeters and Optimum Oxygen Saturation in Premature Infants

Targeting oxygen saturation below 90% is associated with increased mortality.

The optimum oxygenation for preterm infants remains controversial. The international Benefits of Oxygen Saturation Targeting (BOOST) II is one of four recent large trials to examine the effects of lower (85%–89%) versus higher (91%-95%) oxygen saturation targets in preterm infants (gestational age ≤27 weeks).

In the first 1261 randomized infants, researchers discovered that the oximeters programmed to obtain the desired oxygen saturation resulted in overlapping target ranges because of a calibration problem. No difference in mortality was discerned in these infants. Oximeters were adjusted to obtain the desired ranges for the subsequent 1187 infants. Interim analysis of these infants at a gestational age of 36 weeks revealed significantly hi…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Oximeters and Optimum Oxygen Saturation in Premature Infants

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Reviewing Author