Using Biomarkers to Predict Cancer Risk in HIV-Infected Patients?

Modifying traditional risk factors, together with appropriate risk-based clinical surveillance, remains the best bet for early detection of cancer in these individuals.

Previous studies have suggested that HIV-infected individuals are at increased risk for cancers both related and unrelated to underlying viral infections. A higher prevalence of traditional risk factors (smoking, alcohol use) in HIV-infected individuals, immune dysregulation in the setting of low CD4-cell counts, and a proinflammatory state may all be contributory.

Now, researchers have evaluated the association between baseline levels of inflammatory (interleukin [IL]-6, C-reactive protein [CRP]) and coagulation (d-dimer) biomarkers and subsequent development of various cancers in HIV-infected individuals. Data were taken from control-arm participants in three randomized, controlled trials (SMART, ESPRIT, and SILCAAT). Cancers were included…

Reviewing Author

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Sonia Nagy Chimienti, MD

Disclosures

Nothing to disclose

Using Biomarkers to Predict Cancer Risk in HIV-Infected Patients?

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Reviewing Author