Is Intensive Blood Pressure Lowering Beneficial in Acute Intracerebral Hemorrhage?

Equivocal outcomes from the INTERACT 2 trial

The INTERACT 1 trial (JW Neurol Aug 14 2012) gave preliminary evidence that early, intensive blood pressure lowering might improve intracerebral hemorrhage (ICH) outcomes. Now, researchers report the findings of INTERACT 2. They enrolled patients with acute, spontaneous ICH whose blood pressure could be treated within 6 hours of symptom onset and lacked an overt structural cause, who were not in deep coma and not scheduled for immediate surgery. Patients were randomized to an intensive systolic blood pressure (SBP) target of <140 mm Hg within 1 hour of randomization, maintained for 7 days, or a conventional, guideline-determined SBP target of <180 mm Hg. The primary outcome was death or major disability at 90 days. A secondary analysis asse…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Is Intensive Blood Pressure Lowering Beneficial in Acute Intracerebral Hemorrhage?

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Reviewing Author