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Regular sunscreen use protects against cutaneous squamous cell carcinomas and invasive melanomas, but its effect on cutaneous photoaging has received much less attention, despite a popular preoccupation with aging and a multibillion dollar industry focused on reversing its effects.
Investigators conducted a randomized, double-blind, controlled trial in 604 subjects younger than 55, most fair-skinned, to evaluate whether regular sunscreen use prevented photoaging of the skin. Approximately half of the participants were randomized to daily application of an SPF15 sunscreen (containing 8% ethylhexyl-p-methoxycinnamate and 2% 4-tert-butyl-4' methoxy-4-dibenzoylmethane); the other half were given no instructions and applied sunscreen at their own…