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Low functioning of the N-methyl-D-aspartate (NMDA) receptor has been hypothesized for schizophrenia. Clinical evidence for this hypothesis includes psychotic effects of phencyclidine, which acts at the NMDA receptor, and preliminary positive findings of treatment with d-serine, a co-agonist at the NMDA receptor (JW Psychiatry Sep 3 2010). In mice, prenatal deprivation of d-serine produced adults that exhibited prepulse inhibition defects and other behaviors associated with schizophrenia, and these impairments were reversed with d-serine administration (PLoS One 2013; 8:e62438). Researchers have now tested in mice whether NMDA hypofunction produced by decreases in serine racemase (SR), the enzyme that converts l-serine to d-serine, could pro…