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Common polymorphisms in genes encoding cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex 1 (VKORC1) are known to alter response to warfarin. However, these polymorphisms explain variability in response more often in whites than in blacks.
To determine whether blacks have unique genetic variants that affect sensitivity to warfarin, investigators conducted a genome-wide association study involving black patients who were on stable maintenance doses of warfarin.
In a discovery cohort of 533 participants, the strongest association with warfarin dose was observed with a novel single nucleotide polymorphism (rs12777823) in the CYP2C gene cluster. This association was confirmed in a replication cohort of 432 persons. Inclusion of …