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Although the presence of autoantibodies to islet cells often precedes the development of type 1 diabetes, the natural history of progression to diabetes following seroconversion remains unknown. Researchers pooled data from three international prospective birth-cohort studies involving 13,377 children genetically at risk for type 1 diabetes. All children were tested for antibodies to insulin, glutamic acid decarboxylase 65, and insulinoma antigen 2, and were screened for diabetes at multiple intervals. Children were recruited between 1989 and 2009 and followed until 2012.
Overall, 1059 children (7.9%) developed autoantibodies (4.4% developed multiple islet autoantibodies) and 428 children developed diabetes, including 25 children without aut…