Novel Cycloviruses Found in CSF

Researchers independently identified new cyclovirus species in the cerebrospinal fluid of Vietnamese and Malawian patients with neurologic disease.

In many patients with suspected central nervous system (CNS) infection, the specific cause remains unidentified. Using an amplified fragment length polymorphism–based virus discovery assay and next-generation sequencing, Tan and colleagues identified and characterized the full genome of a novel cyclovirus in cerebrospinal fluid (CSF) specimens from two patients in Vietnam with CNS infections of unknown etiology. They then used real-time polymerase chain reaction (PCR) to analyze additional samples for evidence of this virus.

Cyclovirus DNA was detected in 26 (4%) of 642 CSF samples from Vietnamese patients with suspected acute CNS infections — 10 (3.7%) of 273 samples from individuals with infection of unknown etiology and 16 (4.3%) of 369 f…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Novel Cycloviruses Found in CSF

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Reviewing Author