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In the first prospective study to correlate prenatal binge drinking and number of daily drinks with dysmorphic physical features in newborns, the first trimester was the most vulnerable time for the teratogenic effects of alcohol exposure (NEJM JW Pediatr Adolesc Med Feb 29 2012). In-utero alcohol exposure might also affect brain development and increase risk for neurodevelopmental disorders in the absence of physical features of fetal alcohol syndrome. To examine the effect of prenatal alcohol exposure on cognition, researchers in Australia linked prospective data from a randomly selected birth cohort of 4056 infants (86% of the cohort) and education records at age 8 to 9 years.
Based on mothers' reports at 3 months after delivery, 41% of m…