CD4-Cell Nadir Before ART and Serious Non-AIDS Events

In HIV-infected patients with baseline CD4 counts >500 cells/mm³, a CD4 nadir <350 cells/mm³ before ART initiation was associated with a higher rate of serious non-AIDS events.

Despite emerging expert opinion recommending antiretroviral therapy (ART) initiation at high CD4 counts (i.e., >500 cells/mm³), data documenting the clinical benefit remain limited. Now, researchers in Spain summarize their experience with HIV-infected patients who had CD4 counts >500 cells/mm³ at baseline and for at least 1 year of follow-up.

Of the 574 patients (median age, 43; median baseline CD4 count, 630 cells/mm³; median baseline viral load, 4 log copies/mL), 80% were men, 57% were men who have sex with men, and 28% had hepatitis C virus coinfection. During a median follow-up of 10 years, 78% initiated ART. Severe non-AIDS clinical events were defined as first hospital admissions for non–AIDS-defining cancers or cardiovascular, neurop…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

CD4-Cell Nadir Before ART and Serious Non-AIDS Events

Topics

Reviewing Author