Response to Treatment for Alcohol Dependence: Genotype Predictors

Approximately 34% of these alcohol-dependent patients carried a genotype combination predictive of treatment response to ondansetron.

Personalized medicine promises clinicians the tools to tailor-make treatments for patients based on their genetic profiles. In a previous randomized, placebo-controlled, double-blind study of the specific serotonin-3 (5-HT₃) antagonist ondansetron in 283 alcohol-dependent individuals without comorbid axis I diagnoses, ondansetron recipients who carried a combination of two genetic variants on the 5-HT transporter gene drank less and had a higher percentage of abstinent days than noncarriers (NEJM JW Psychiatry Feb 18 2011).

Extending this work, researchers examined treatment effects of 5-HT receptor polymorphisms in these patients. After examining 19 polymorphism variants in genes that influence ondansetron's actions (HTR_3A and HTR_3B, which …

Reviewing Author

Joel Yager, MD

Disclosures

Editorial BoardsInternational Journal of Eating Disorders; UpToDate; FOCUS: The Journal of Lifelong Learning in Psychiatry; American Journal of Psychotherapy

Joel Yager, MD

Disclosures

Editorial BoardsInternational Journal of Eating Disorders; UpToDate; FOCUS: The Journal of Lifelong Learning in Psychiatry; American Journal of Psychotherapy

Response to Treatment for Alcohol Dependence: Genotype Predictors

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Reviewing Author