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Optic neuritis (ON) is the most common presentation of multiple sclerosis (MS) and a prototypic example of acute demyelinating injury. Advances in retinal imaging and electrophysiology have allowed ON to serve as a unique clinical model for evaluating acute central nervous system demyelination by providing accurate measures of the anatomic and functional consequences of acute ON. The optic nerve head component (ONHC) response is an electrophysiologic correlate of the multifocal electroretinogram that signifies a change from membranous (unmyelinated) to saltatory (myelinated) conduction in healthy people. Therefore, abnormalities in the ONHC may provide a sensitive metric for the severity of injury following acute ON.
In this pilot investigat…