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Celiac disease is a risk factor for T-cell lymphomas of the intestine as well as a variety of other malignancies. Some experts believe that adherence to a gluten-free diet mitigates this risk. Guidelines suggest repeating serologic testing after several months on a gluten-free diet (Am J Gastroenterol 2013; 108:656), but follow-up biopsy sampling to confirm healing is not routinely performed. Now, researchers consider its value for assessing cancer risk.
To examine the association between mucosal healing in celiac disease and the risk for lymphoproliferative malignancy (LPM), investigators in Sweden conducted a retrospective, population-based cohort study of 7625 patients with celiac disease who had at least one follow-up biopsy taken after …