AIDS Complications at High CD4-Cell Counts

Factors associated with increased risk for AIDS-defining illnesses at CD4 counts ≥500 cells/mm³ included acquiring HIV via intravenous drug use and viral load >10,000 copies/mL.

With current HIV therapy, most patients in developed countries achieve virologic suppression and immune reconstitution. Although the risk for AIDS in those with high CD4-cell counts is low, it is not zero. Now, using data from 33 cohorts in Europe, researchers have assessed the incidence of AIDS-defining illnesses (ADIs) at CD4 counts ≥200 cells/mm³ beginning in 1998 — the start of the current HIV treatment era.

In all, 207,539 individuals aged ≥14 with baseline CD4 counts ≥200 cells/mm³ (median, 378) were included in the analysis. The largest risk category was men who have sex with men (40%), followed by women who acquired HIV through heterosexual contact (20%). A total of 12,135 ADIs occurred during a total of 1,154,803 person-years of fol…

Reviewing Author

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

Paul E. Sax, MD

Disclosures

Consultant/Advisory BoardGilead Sciences; GlaxoSmithKline/ViiV; Merck; Shionogi

Grant/Research SupportNIH; Gilead Sciences; ViiV

Editorial BoardsUpToDate; Clinical Infectious Diseases

AIDS Complications at High CD4-Cell Counts

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Reviewing Author