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Australia approved two rotavirus vaccines, RV1 (Rotarix) and RV5 (RotaTeq), in 2007. As part of Australia's postmarketing surveillance, researchers compared intussusception in infants (aged 1 to 12 months) during the 21 days after rotavirus vaccination and during the period before or more than 21 days after vaccination. Using hospital discharge databases and active surveillance from 2007 through 2010, investigators identified 306 confirmed cases of intussusception.
After the first RV1 and RV5 doses, the relative incidence (RI) of intussusception was highest during week 1 (6.8 and 9.9, respectively) and dropped by 50% between weeks 1 and 3 (to 3.5 and 6.3, respectively). After the second dose of both vaccines, there was a smaller increased ri…