HIV-infected patients who tested HCV antibody positive were more likely to develop kidney disease than those who tested negative, whether or not they had HCV viremia.
Hepatitis C virus (HCV) infection has been linked to an increased risk for chronic kidney disease (CKD) in both HIV-infected and -uninfected individuals. To evaluate the factors that mediate this connection, including the role of hepatitis C viremia, investigators compared the rates of CKD among HIV-infected patients who were HCV seronegative, HCV seropositive and HCV viremic, or HCV seropositive and HCV aviremic.
The study involved 63,023 NA-ACCORD participants (52,602 HCV seronegative, 9508 HCV viremic, 913 HCV aviremic). Baseline serum creatinine levels and estimated glomerular filtration rates were similar across the three groups. In analyses adjusted for factors associated with renal dysfunction (including race, HIV RNA level, CD4-cell …
Reviewing Author
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)