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Interventions for carpal tunnel syndrome include wrist splints, surgery, or steroid injections, although data to support steroid injections are sparse. To evaluate the efficacy of steroid injections for alleviating carpal tunnel pain, a group from Sweden randomized 111 patients to single injections of methylprednisolone (80 mg or 40 mg) or placebo. Patients were included if a 2-month trial of wrist splinting failed and if they had never received steroid injections; they could elect to undergo surgery 3 months after study enrollment if their symptoms didn't improve.
At 10 weeks, mean carpal tunnel symptom scores (range, 1–5) had improved significantly more in the methylprednisolone groups than in the placebo group (change from baseline vs. pl…